مقایسه نسبت آلبومین به کراتینین ادرار بیماران مبتلا به فشارخون با هیپرتروفی بطن چپ و بیماران فاقد آن

Background and purpose: Echocardiography and routine E.C.G are standard methods for left ventricular hypertrophy (LVH). However, urine albumin to creatinine ratio (UACR) recommended by recent investigations is more available and less expensive than echocardiography for detection of LVH. Materials and Methods: According to inclusion and exclusion criteria, 124 hypertensive patients (62 cases with LVH and 62 cases without LVH) were selected and divided into two groups. Eechocardiography and routine E.C.G were done for all patients. Urine albumin (nephlometric methods) and creatinine were measured and in patients with urine albumin>100mg/dl, ACR was calculated. Results: No significant differences were observed in mean B.U.N and creatinine, FBS and BMI between two groups. The comparison of UACR between two groups indicates that the frequency of patients with UACR> 100 mg/g in group with LVH, was more than the group without LVH (sensitivity 32.5% and specificity 92%). By combination of these tests a higher sensitivity was obtained (with Cornell criteria 37.1%).Thus, if UACR > 100 is combined with one of the markers of E.C.G for LVH diagnosis, more cases would be detected. Conclusion: Albumin to creatinine ratio in a randomized urine sample, in hypertensive patients. with LVH is higher than patients without LVH and UACR>100 can be applied for diagnosis of LVH More over by combination of E.C.G to ACR a higher sensitivity would be obtained.